Sequential release of nanoparticle payloads from ultrasonically burstable capsules

Sequential release of nanoparticle payloads from ultrasonically burstable capsules.

In many biomedical contexts ranging from chemotherapy to tissue engineering, it is beneficial to sequentially present bioactive payloads. Explicit control over the timing and dose of these presentations is highly desirable. Here, we present a capsule-based delivery system capable of rapidly releasing multiple payloads in response to ultrasonic signals. In vitro, these alginate capsules exhibite...

Nanocomposite capsules with directional, pulsed nanoparticle release

The precise spatiotemporal delivery of nanoparticles from polymeric capsules is required for applications ranging from medicine to materials science. These capsules derive key performance aspects from their overall shape and dimensions, porosity, and internal microstructure. To this effect, microfluidics provide an exceptional platform for emulsification and subsequent capsule formation. Howeve...

Ultrasound-triggered release from multilayered capsules.

The growing need for drug-delivery systems that release their contents in a desired fashion has intensified research for “smart carriers” with intelligent properties. Compared to more established delivery vehicles, such as polymeric micelles, liposomes, and small colloidal particles, polymeric polyelectrolyte multilayered capsules 8] are emerging materials with high potential as macromolecular ...

Controlled release of nanoparticles and macromolecules from responsive microgel capsules.

Using a mesoscale computational model, we probe the release of nanoparticles and linear macromolecules from hollow microgel capsules that swell and deswell in response to external stimuli. Our simulations reveal that responsive microcapsules can be effectively utilized for steady and pulsatile release of encapsulated solutes. Swollen gel capsules allow steady, diffusive release of nanoparticles...

Asasantin Sr Sustained-release Capsules